OSEET
OPTICAL COHERENCE TOMOGRAPHY FOR THE IN-LINE AND AT-LINE MEASUREMENT IN PHARMACEUTICAL TECHNOLOGY

Description du produit

OSeeT is the only existing technology that allows rapid (even in-line/real-time) monitoring of coating quality without calibration and multivariate data analysis for transparent and semi-transparent materials.

OSeeT provides direct information about multiple quality attributes of layers in pharmaceutical products (e.g. coating thickness) and is a link to related critical quality attributes (e.g. API release in dissolution).

OSeeT can also provide indirect information (for scattering materials) from the penetration depth of light into the sample which can be linked e.g. to dissolution behavior or compression force.

Working principle

• OCT is based on (coherence gated) interferometry.
• Light is split in reference and probe path.
• Optics of the sample arm focus light and define lateral (=surface) resolution in focus.
• Interference of light reflected back from both paths.
• Spectrometer (grating, high-speed CMOS sensor).
• Depth-information is generated from interference by non- linear Fourier-transformation (nu-FFT).
• Depth scan measurement rate: 130 – 250 kHz (depending on OSeeT system version).
• Direct thickness measurement (optical path length).
• Each interferogram -> one depth reading (“A-scan”, 1D). A-scan rate: 130kHz-250kHz max.
• Multiple A-scans -> cross-sectional image (“B-scan”, 2D). Requires moving of objects or a scanning sensor beam.